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PTPRD protein tyrosine phosphatase receptor type D [ Homo sapiens (human) ]

Gene ID: 5789, updated on 2-Nov-2024

Summary

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Official Symbol
PTPRDprovided by HGNC
Official Full Name
protein tyrosine phosphatase receptor type Dprovided by HGNC
Primary source
HGNC:HGNC:9668
See related
Ensembl:ENSG00000153707 MIM:601598; AllianceGenome:HGNC:9668
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPTP; PTPD; HPTPD; HPTPDELTA; RPTPDELTA; R-PTP-delta
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010]
Expression
Broad expression in brain (RPKM 18.0), kidney (RPKM 8.8) and 14 other tissues See more
Orthologs
mouse all
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Genomic context

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See PTPRD in Genome Data Viewer
Location:
9p24.1-p23
Exon count:
51
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (8314246..10613002, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (8320802..10622316, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (8314246..10613002, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:7799542-7800088 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:7879626-7880126 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:7880127-7880627 Neighboring gene uncharacterized LOC105375971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28213 Neighboring gene VISTA enhancer hs304 Neighboring gene distal membrane arm assembly component 1 Neighboring gene Sharpr-MPRA regulatory region 3353 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:8485393-8486592 Neighboring gene NANOG hESC enhancer GRCh37_chr9:8514616-8515117 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:8600067-8600567 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:8643271-8644250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:8644251-8645230 Neighboring gene ribosomal protein L18a pseudogene 11 Neighboring gene RNA, U7 small nuclear 185 pseudogene Neighboring gene PTPRD antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 1388 Neighboring gene ribosomal protein S26 pseudogene 3 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:9556889-9557562 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:9577422-9577610 Neighboring gene RNA, 7SL, cytoplasmic 5, pseudogene Neighboring gene uncharacterized LOC105375972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:9914591-9915090 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:9998786-9999985 Neighboring gene NANOG hESC enhancer GRCh37_chr9:10011672-10012190 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19773 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:10633883-10634384 Neighboring gene PTPRD divergent transcript Neighboring gene IMP3 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Aberrant splicing of the PTPRD gene mimics microdeletions identified at this locus in neuroblastomas. Nair P, et al. Genes Chromosomes Cancer, 2008 Mar. PMID 18050303
  2. Protein tyrosine phosphatases receptor type D is a potential tumour suppressor gene inactivated by deoxyribonucleic acid methylation in paediatric acute myeloid leukaemia. Song L, et al. Acta Paediatr, 2016 Mar. PMID 26607758
  3. Identification of chromosome arm 9p as the most frequent target of homozygous deletions in lung cancer. Sato M, et al. Genes Chromosomes Cancer, 2005 Dec. PMID 16114034
  4. Loss of Tyrosine Phosphatase Delta Promotes Gastric Cancer Progression via Signal Transducer and Activator of Transcription 3 Pathways. Wu L, et al. Dig Dis Sci, 2019 Nov. PMID 31041642
  5. Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses. Painter JN, et al. Cancer Med, 2018 May. PMID 29608257, Free PMC Article

See all (126) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protein tyrosine phosphatase receptor type D gene promotes radiosensitivity via STAT3 dephosphorylation in nasopharyngeal carcinoma.
    Title: Protein tyrosine phosphatase receptor type D gene promotes radiosensitivity via STAT3 dephosphorylation in nasopharyngeal carcinoma.
  2. Metastasis suppressor 1 interacts with protein tyrosine phosphatase receptor-delta to regulate adipogenesis.
    Title: Metastasis suppressor 1 interacts with protein tyrosine phosphatase receptor-δ to regulate adipogenesis.
  3. PTPRD and CNTNAP2 as markers of tumor aggressiveness in oligodendrogliomas.
    Title: PTPRD and CNTNAP2 as markers of tumor aggressiveness in oligodendrogliomas.
  4. Methylation-mediated silencing of PTPRD induces pulmonary hypertension by promoting pulmonary arterial smooth muscle cell migration via the PDGFRB/PLCgamma1 axis.
    Title: Methylation-mediated silencing of PTPRD induces pulmonary hypertension by promoting pulmonary arterial smooth muscle cell migration via the PDGFRB/PLCγ1 axis.
  5. An integrative prognostic and immune analysis of PTPRD in cancer.
    Title: An integrative prognostic and immune analysis of PTPRD in cancer.
  6. Structure-activity studies of PTPRD phosphatase inhibitors identify a 7-cyclopentymethoxy illudalic acid analog candidate for development.
    Title: Structure-activity studies of PTPRD phosphatase inhibitors identify a 7-cyclopentymethoxy illudalic acid analog candidate for development.
  7. Identification and validation of tissue or ctDNA PTPRD phosphatase domain deleterious mutations as prognostic and predictive biomarkers for immune checkpoint inhibitors in non-squamous NSCLC.
    Title: Identification and validation of tissue or ctDNA PTPRD phosphatase domain deleterious mutations as prognostic and predictive biomarkers for immune checkpoint inhibitors in non-squamous NSCLC.
  8. IL1RAP regulated by PRPRD promotes gliomas progression via inducing neuronal synapse development and neuron differentiation in vitro.
    Title: IL1RAP regulated by PRPRD promotes gliomas progression via inducing neuronal synapse development and neuron differentiation in vitro.
  9. Altered PTPRD DNA methylation associates with restricted adipogenesis in healthy first-degree relatives of Type 2 diabetes subjects.
    Title: Altered PTPRD DNA methylation associates with restricted adipogenesis in healthy first-degree relatives of Type 2 diabetes subjects.
  10. DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk.
    Title: DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk.
Submit: New GeneRIF Correction See all GeneRIFs (68)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy.
EBI GWAS Catalog
A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese.
EBI GWAS Catalog
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
EBI GWAS Catalog
A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.
EBI GWAS Catalog
Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.
EBI GWAS Catalog
Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.
EBI GWAS Catalog
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog
Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals.
EBI GWAS Catalog
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
EBI GWAS Catalog
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
EBI GWAS Catalog
Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.
EBI GWAS Catalog
Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS.
EBI GWAS Catalog
Genome-wide association study of co-occurring anxiety in major depression.
EBI GWAS Catalog
Genome-Wide Association Study of Primary Dentition Pit-and-Fissure and Smooth Surface Caries.
EBI GWAS Catalog
Genome-wide association study of the five-factor model of personality in young Korean women.
EBI GWAS Catalog
Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.
EBI GWAS Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog
Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog
PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC119750, MGC119751, MGC119752, MGC119753

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cell adhesion molecule binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transmembrane receptor protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine phosphatase signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
involved_in modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphate-containing compound metabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in presynapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in presynapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in presynaptic membrane assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynaptic density assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic membrane adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic membrane adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic membrane adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic membrane adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in trans-synaptic signaling by trans-synaptic complex IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in trans-synaptic signaling by trans-synaptic complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in hippocampal mossy fiber to CA3 synapse IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
receptor-type tyrosine-protein phosphatase delta
Names
protein tyrosine phosphatase, receptor type, delta polypeptide
rceptor-type tyrosine-protein phosphatase delta
NP_001035802.1
NP_001164496.1
NP_001364875.1
NP_001364876.1
NP_001364887.1
NP_001364987.1
NP_002830.1
NP_569075.2
NP_569076.2
NP_569077.2
XP_006716880.1
XP_006716886.1
XP_006716888.1
XP_006716890.1
XP_016870447.1
XP_016870450.1
XP_016870452.1
XP_016870453.1
XP_016870454.1
XP_016870455.1
XP_016870456.1
XP_016870457.1
XP_016870458.1
XP_016870459.1
XP_016870460.1
XP_016870461.1
XP_016870463.1
XP_016870465.1
XP_016870466.1
XP_016870467.1
XP_016870468.1
XP_016870469.1
XP_016870471.1
XP_016870472.1
XP_024303393.1
XP_047279597.1
XP_047279598.1
XP_047279599.1
XP_047279600.1
XP_047279601.1
XP_047279602.1
XP_047279603.1
XP_047279604.1
XP_047279605.1
XP_047279606.1
XP_047279607.1
XP_047279608.1
XP_047279609.1
XP_047279610.1
XP_047279611.1
XP_047279612.1
XP_047279613.1
XP_047279614.1
XP_047279615.1
XP_047279616.1
XP_054219364.1
XP_054219365.1
XP_054219366.1
XP_054219367.1
XP_054219368.1
XP_054219369.1
XP_054219370.1
XP_054219371.1
XP_054219372.1
XP_054219373.1
XP_054219374.1
XP_054219375.1
XP_054219376.1
XP_054219377.1
XP_054219378.1
XP_054219379.1
XP_054219380.1
XP_054219381.1
XP_054219382.1
XP_054219383.1
XP_054219384.1
XP_054219385.1
XP_054219386.1
XP_054219387.1
XP_054219388.1
XP_054219389.1
XP_054219390.1
XP_054219391.1
XP_054219392.1
XP_054219393.1
XP_054219394.1
XP_054219395.1
XP_054219396.1
XP_054219397.1
XP_054219398.1
XP_054219399.1
XP_054219400.1
XP_054219401.1
XP_054219402.1
XP_054219403.1
XP_054219404.1
XP_054219405.1
XP_054219406.1
XP_054219407.1
XP_054219408.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033963.1 RefSeqGene

    Range
    4722..2303478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001040712.2 → NP_001035802.1  receptor-type tyrosine-protein phosphatase delta isoform 5 precursor

    See identical proteins and their annotated locations for NP_001035802.1

    Status: REVIEWED

    Source sequence(s)
    AB208869, AL356584, AL445926, AL590397, BM680342, DR001889
    Consensus CDS
    CCDS55288.1
    UniProtKB/TrEMBL
    F5GWR7
    Related
    ENSP00000380735.3, ENST00000397611.7
    Conserved Domains (8) summary
    cd05738
    Location:143 → 223
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:247 → 315
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:946 → 1201
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:132 → 222
    IG_like; Immunoglobulin like
    cd00047
    Location:972 → 1201
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:320 → 409
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:24 → 115
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:41 → 115
    Ig; Immunoglobulin domain

  2. NM_001171025.2 → NP_001164496.1  receptor-type tyrosine-protein phosphatase delta isoform 6 precursor

    See identical proteins and their annotated locations for NP_001164496.1

    Status: REVIEWED

    Source sequence(s)
    AL137125, AL356584, AL445926, AL583805, AL590397, AL596451
    Consensus CDS
    CCDS55289.1
    UniProtKB/TrEMBL
    F5GWR7
    Related
    ENSP00000380731.3, ENST00000397606.7
    Conserved Domains (8) summary
    cd05738
    Location:143 → 220
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:240 → 308
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:949 → 1204
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:132 → 219
    IG_like; Immunoglobulin like
    cd00047
    Location:975 → 1204
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:313 → 402
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:24 → 115
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:41 → 115
    Ig; Immunoglobulin domain

  3. NM_001377946.1 → NP_001364875.1  receptor-type tyrosine-protein phosphatase delta isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AL137125, AL356584, AL445926, AL583805, AL590397, AL596451
    UniProtKB/TrEMBL
    F5GWR7
    Conserved Domains (7) summary
    cd00063
    Location:317 → 406
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14624
    Location:931 → 1214
    R-PTPc-D-1; catalytic domain of receptor-type tyrosine-protein phosphatase D, repeat 1
    cd14628
    Location:1215 → 1506
    R-PTP-D-2; PTP-like domain of receptor-type tyrosine-protein phosphatase D, repeat 2
    pfam07679
    Location:24 → 115
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:32 → 36
    Ig; Ig strand A' [structural motif]
    cd05738
    Location:127 → 220
    IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
    cd05739
    Location:233 → 314
    IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

  4. NM_001377947.1 → NP_001364876.1  receptor-type tyrosine-protein phosphatase delta isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AL137125, AL356584, AL445926, AL583805, AL590397, AL596451
    UniProtKB/TrEMBL
    F5GWR7
    Conserved Domains (7) summary
    cd00063
    Location:320 → 409
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14624
    Location:921 → 1204
    R-PTPc-D-1; catalytic domain of receptor-type tyrosine-protein phosphatase D, repeat 1
    cd14628
    Location:1205 → 1496
    R-PTP-D-2; PTP-like domain of receptor-type tyrosine-protein phosphatase D, repeat 2
    pfam07679
    Location:24 → 115
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:32 → 36
    Ig; Ig strand A' [structural motif]
    cd05738
    Location:127 → 223
    IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
    cd05739
    Location:236 → 317
    IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

  5. NM_001377958.1 → NP_001364887.1  receptor-type tyrosine-protein phosphatase delta isoform 9 precursor

    Status: REVIEWED

    Source sequence(s)
    AL137125, AL356584, AL445926, AL583805, AL590397, AL596451
    UniProtKB/TrEMBL
    Q2HXI4
    Conserved Domains (7) summary
    cd00063
    Location:922 → 1013
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14624
    Location:1354 → 1637
    R-PTPc-D-1; catalytic domain of receptor-type tyrosine-protein phosphatase D, repeat 1
    cd14628
    Location:1638 → 1929
    R-PTP-D-2; PTP-like domain of receptor-type tyrosine-protein phosphatase D, repeat 2
    pfam07679
    Location:24 → 115
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:32 → 36
    Ig; Ig strand A' [structural motif]
    cd05738
    Location:127 → 226
    IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
    cd05739
    Location:239 → 320
    IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

  6. NM_001378058.1 → NP_001364987.1  receptor-type tyrosine-protein phosphatase delta isoform 10 precursor

    Status: REVIEWED

    Source sequence(s)
    AL137125, AL356584, AL445926, AL583805, AL590397, AL596451
    UniProtKB/TrEMBL
    Q2HXI4
    Conserved Domains (7) summary
    cd00063
    Location:922 → 1013
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14624
    Location:1339 → 1622
    R-PTPc-D-1; catalytic domain of receptor-type tyrosine-protein phosphatase D, repeat 1
    cd14628
    Location:1623 → 1914
    R-PTP-D-2; PTP-like domain of receptor-type tyrosine-protein phosphatase D, repeat 2
    pfam07679
    Location:24 → 115
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:32 → 36
    Ig; Ig strand A' [structural motif]
    cd05738
    Location:127 → 226
    IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
    cd05739
    Location:239 → 320
    IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

  7. NM_002839.4 → NP_002830.1  receptor-type tyrosine-protein phosphatase delta isoform 1 precursor

    See identical proteins and their annotated locations for NP_002830.1

    Status: REVIEWED

    Source sequence(s)
    AB211400, AL135790, AL356584, AL390723, AL445926, BC028038, BM680342
    Consensus CDS
    CCDS43786.1
    UniProtKB/Swiss-Prot
    B1ALA0, F5GWT7, P23468, Q3KPJ0, Q3KPJ1, Q3KPJ2
    UniProtKB/TrEMBL
    Q2HXI4
    Related
    ENSP00000370593.3, ENST00000381196.9
    Conserved Domains (8) summary
    cd05738
    Location:143 → 226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250 → 318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:1356 → 1611
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:132 → 225
    IG_like; Immunoglobulin like
    cd00047
    Location:1382 → 1611
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:922 → 1013
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:24 → 115
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:41 → 115
    Ig; Immunoglobulin domain

  8. NM_130391.4 → NP_569075.2  receptor-type tyrosine-protein phosphatase delta isoform 2 precursor

    See identical proteins and their annotated locations for NP_569075.2

    Status: REVIEWED

    Source sequence(s)
    AL137125, AL356584, AL445926, AL451130, AL583805, AL590397
    Consensus CDS
    CCDS6472.2
    UniProtKB/TrEMBL
    F5GWR7
    Related
    ENSP00000417093.1, ENST00000486161.5
    Conserved Domains (8) summary
    cd05738
    Location:143 → 226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250 → 318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:949 → 1204
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:132 → 225
    IG_like; Immunoglobulin like
    cd00047
    Location:975 → 1204
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:323 → 412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:24 → 115
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:41 → 115
    Ig; Immunoglobulin domain

  9. NM_130392.3 → NP_569076.2  receptor-type tyrosine-protein phosphatase delta isoform 3 precursor

    See identical proteins and their annotated locations for NP_569076.2

    Status: REVIEWED

    Source sequence(s)
    AL445926, BC106714, BM680342, DR001889
    Consensus CDS
    CCDS55290.1
    UniProtKB/TrEMBL
    F5GWR7
    Related
    ENSP00000347373.5, ENST00000355233.9
    Conserved Domains (8) summary
    cd05738
    Location:143 → 226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250 → 318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:950 → 1205
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:132 → 225
    IG_like; Immunoglobulin like
    cd00047
    Location:976 → 1205
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:323 → 412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:24 → 115
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:41 → 115
    Ig; Immunoglobulin domain

  10. NM_130393.3 → NP_569077.2  receptor-type tyrosine-protein phosphatase delta isoform 4 precursor

    See identical proteins and their annotated locations for NP_569077.2

    Status: REVIEWED

    Source sequence(s)
    AL445926, AL590397, BC106716, BM680342, DR001889
    Consensus CDS
    CCDS75813.1
    UniProtKB/TrEMBL
    F5GWR7, F5GWY7, Q3KPI9
    Related
    ENSP00000440515.2, ENST00000537002.5
    Conserved Domains (8) summary
    cd05738
    Location:143 → 220
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:244 → 312
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:940 → 1195
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:132 → 219
    IG_like; Immunoglobulin like
    cd00047
    Location:966 → 1195
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:317 → 406
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:24 → 115
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:41 → 115
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    8314246..10613002 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014961.3 → XP_016870450.1  receptor-type tyrosine-protein phosphatase delta isoform X1

    UniProtKB/TrEMBL
    Q2HXI4
    Conserved Domains (7) summary
    cd00063
    Location:922 → 1013
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14624
    Location:1354 → 1637
    R-PTPc-D-1; catalytic domain of receptor-type tyrosine-protein phosphatase D, repeat 1
    cd14628
    Location:1638 → 1929
    R-PTP-D-2; PTP-like domain of receptor-type tyrosine-protein phosphatase D, repeat 2
    pfam07679
    Location:24 → 115
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:32 → 36
    Ig; Ig strand A' [structural motif]
    cd05738
    Location:127 → 226
    IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
    cd05739
    Location:239 → 320
    IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

  2. XM_006716827.5 → XP_006716890.1  receptor-type tyrosine-protein phosphatase delta isoform X38

    UniProtKB/TrEMBL
    Q2HXI4
    Conserved Domains (8) summary
    cd05738
    Location:143 → 217
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:237 → 305
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:1337 → 1592
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:132 → 216
    IG_like; Immunoglobulin like
    cd00047
    Location:1363 → 1592
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:900 → 991
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:24 → 115
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:41 → 115
    Ig; Immunoglobulin domain

  3. XM_047423649.1 → XP_047279605.1  receptor-type tyrosine-protein phosphatase delta isoform X28

  4. XM_047423651.1 → XP_047279607.1  receptor-type tyrosine-protein phosphatase delta isoform X30

  5. XM_047423657.1 → XP_047279613.1  receptor-type tyrosine-protein phosphatase delta isoform X37

  6. XM_047423653.1 → XP_047279609.1  receptor-type tyrosine-protein phosphatase delta isoform X33

  7. XM_017014971.3 → XP_016870460.1  receptor-type tyrosine-protein phosphatase delta isoform X13

    UniProtKB/TrEMBL
    Q2HXI4

  8. XM_024447625.2 → XP_024303393.1  receptor-type tyrosine-protein phosphatase delta isoform X12

    UniProtKB/TrEMBL
    Q2HXI4
    Conserved Domains (6) summary
    cd05739
    Location:243 → 311
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:1656 → 1915
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:1395 → 1624
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:915 → 1006
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:24 → 115
    I-set; Immunoglobulin I-set domain
    cd05738
    Location:143 → 223
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

  9. XM_017014966.3 → XP_016870455.1  receptor-type tyrosine-protein phosphatase delta isoform X6

    UniProtKB/TrEMBL
    Q2HXI4

  10. XM_017014969.3 → XP_016870458.1  receptor-type tyrosine-protein phosphatase delta isoform X11

    UniProtKB/TrEMBL
    Q2HXI4

  11. XM_047423645.1 → XP_047279601.1  receptor-type tyrosine-protein phosphatase delta isoform X23

  12. XM_017014967.3 → XP_016870456.1  receptor-type tyrosine-protein phosphatase delta isoform X7

    UniProtKB/TrEMBL
    Q2HXI4

  13. XM_017014983.3 → XP_016870472.1  receptor-type tyrosine-protein phosphatase delta isoform X43

    UniProtKB/TrEMBL
    F5GWR7

  14. XM_017014982.3 → XP_016870471.1  receptor-type tyrosine-protein phosphatase delta isoform X42

    UniProtKB/TrEMBL
    F5GWR7

  15. XM_047423654.1 → XP_047279610.1  receptor-type tyrosine-protein phosphatase delta isoform X34

  16. XM_017014980.3 → XP_016870469.1  receptor-type tyrosine-protein phosphatase delta isoform X31

    UniProtKB/TrEMBL
    Q2HXI4
    Conserved Domains (8) summary
    cd05738
    Location:143 → 226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250 → 318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:1347 → 1602
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:132 → 225
    IG_like; Immunoglobulin like
    cd00047
    Location:1373 → 1602
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:913 → 1004
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:24 → 115
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:41 → 115
    Ig; Immunoglobulin domain

  17. XM_047423644.1 → XP_047279600.1  receptor-type tyrosine-protein phosphatase delta isoform X19

  18. XM_017014974.3 → XP_016870463.1  receptor-type tyrosine-protein phosphatase delta isoform X15

    UniProtKB/TrEMBL
    Q2HXI4

  19. XM_047423652.1 → XP_047279608.1  receptor-type tyrosine-protein phosphatase delta isoform X32

  20. XM_047423650.1 → XP_047279606.1  receptor-type tyrosine-protein phosphatase delta isoform X29

  21. XM_017014977.3 → XP_016870466.1  receptor-type tyrosine-protein phosphatase delta isoform X17

    UniProtKB/TrEMBL
    Q2HXI4

  22. XM_017014972.3 → XP_016870461.1  receptor-type tyrosine-protein phosphatase delta isoform X14

    UniProtKB/TrEMBL
    Q2HXI4

  23. XM_047423647.1 → XP_047279603.1  receptor-type tyrosine-protein phosphatase delta isoform X26

  24. XM_006716817.5 → XP_006716880.1  receptor-type tyrosine-protein phosphatase delta isoform X5

    UniProtKB/TrEMBL
    Q2HXI4
    Conserved Domains (8) summary
    cd05738
    Location:143 → 226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250 → 318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:1373 → 1628
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:132 → 225
    IG_like; Immunoglobulin like
    cd00047
    Location:1399 → 1628
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:922 → 1013
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:24 → 115
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:41 → 115
    Ig; Immunoglobulin domain

  25. XM_047423642.1 → XP_047279598.1  receptor-type tyrosine-protein phosphatase delta isoform X9

  26. XM_017014964.3 → XP_016870453.1  receptor-type tyrosine-protein phosphatase delta isoform X2

    UniProtKB/TrEMBL
    Q2HXI4

  27. XM_006716825.5 → XP_006716888.1  receptor-type tyrosine-protein phosphatase delta isoform X25

    UniProtKB/TrEMBL
    Q2HXI4
    Conserved Domains (8) summary
    cd05738
    Location:143 → 226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250 → 318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:1356 → 1611
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:132 → 225
    IG_like; Immunoglobulin like
    cd00047
    Location:1382 → 1611
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:922 → 1013
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:24 → 115
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:41 → 115
    Ig; Immunoglobulin domain

  28. XM_017014970.3 → XP_016870459.1  receptor-type tyrosine-protein phosphatase delta isoform X10

    UniProtKB/TrEMBL
    Q2HXI4

  29. XM_017014979.3 → XP_016870468.1  receptor-type tyrosine-protein phosphatase delta isoform X21

    UniProtKB/TrEMBL
    Q2HXI4

  30. XM_017014965.3 → XP_016870454.1  receptor-type tyrosine-protein phosphatase delta isoform X4

    UniProtKB/TrEMBL
    Q2HXI4

  31. XM_006716823.4 → XP_006716886.1  receptor-type tyrosine-protein phosphatase delta isoform X22

    UniProtKB/TrEMBL
    Q2HXI4
    Conserved Domains (8) summary
    cd05738
    Location:143 → 226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250 → 318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:1357 → 1612
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:132 → 225
    IG_like; Immunoglobulin like
    cd00047
    Location:1383 → 1612
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:922 → 1013
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:24 → 115
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:41 → 115
    Ig; Immunoglobulin domain

  32. XM_017014968.3 → XP_016870457.1  receptor-type tyrosine-protein phosphatase delta isoform X8

    UniProtKB/TrEMBL
    Q2HXI4
    Conserved Domains (8) summary
    cd05738
    Location:143 → 226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250 → 318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:1371 → 1626
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:132 → 225
    IG_like; Immunoglobulin like
    cd00047
    Location:1397 → 1626
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:922 → 1013
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:24 → 115
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:41 → 115
    Ig; Immunoglobulin domain

  33. XM_017014978.3 → XP_016870467.1  receptor-type tyrosine-protein phosphatase delta isoform X20

    UniProtKB/TrEMBL
    Q2HXI4
    Conserved Domains (8) summary
    cd05738
    Location:143 → 226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250 → 318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:1361 → 1616
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:132 → 225
    IG_like; Immunoglobulin like
    cd00047
    Location:1387 → 1616
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:922 → 1013
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:24 → 115
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:41 → 115
    Ig; Immunoglobulin domain

  34. XM_017014963.3 → XP_016870452.1  receptor-type tyrosine-protein phosphatase delta isoform X3

    UniProtKB/TrEMBL
    Q2HXI4
    Conserved Domains (8) summary
    cd05738
    Location:143 → 226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250 → 318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:1375 → 1630
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:132 → 225
    IG_like; Immunoglobulin like
    cd00047
    Location:1401 → 1630
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:922 → 1013
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:24 → 115
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:41 → 115
    Ig; Immunoglobulin domain

  35. XM_017014976.3 → XP_016870465.1  receptor-type tyrosine-protein phosphatase delta isoform X18

    UniProtKB/TrEMBL
    Q2HXI4

  36. XM_017014958.3 → XP_016870447.1  receptor-type tyrosine-protein phosphatase delta isoform X1

    UniProtKB/TrEMBL
    Q2HXI4
    Conserved Domains (7) summary
    cd00063
    Location:922 → 1013
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14624
    Location:1354 → 1637
    R-PTPc-D-1; catalytic domain of receptor-type tyrosine-protein phosphatase D, repeat 1
    cd14628
    Location:1638 → 1929
    R-PTP-D-2; PTP-like domain of receptor-type tyrosine-protein phosphatase D, repeat 2
    pfam07679
    Location:24 → 115
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:32 → 36
    Ig; Ig strand A' [structural motif]
    cd05738
    Location:127 → 226
    IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
    cd05739
    Location:239 → 320
    IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

  37. XM_047423641.1 → XP_047279597.1  receptor-type tyrosine-protein phosphatase delta isoform X1

  38. XM_047423660.1 → XP_047279616.1  receptor-type tyrosine-protein phosphatase delta isoform X41

  39. XM_047423659.1 → XP_047279615.1  receptor-type tyrosine-protein phosphatase delta isoform X40

  40. XM_047423648.1 → XP_047279604.1  receptor-type tyrosine-protein phosphatase delta isoform X27

  41. XM_047423658.1 → XP_047279614.1  receptor-type tyrosine-protein phosphatase delta isoform X39

  42. XM_047423646.1 → XP_047279602.1  receptor-type tyrosine-protein phosphatase delta isoform X24

    Related
    ENST00000651105.1

  43. XM_047423656.1 → XP_047279612.1  receptor-type tyrosine-protein phosphatase delta isoform X36

  44. XM_047423655.1 → XP_047279611.1  receptor-type tyrosine-protein phosphatase delta isoform X35

  45. XM_047423643.1 → XP_047279599.1  receptor-type tyrosine-protein phosphatase delta isoform X16

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    8320802..10622316 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363390.1 → XP_054219365.1  receptor-type tyrosine-protein phosphatase delta isoform X1

  2. XM_054363428.1 → XP_054219403.1  receptor-type tyrosine-protein phosphatase delta isoform X38

  3. XM_054363418.1 → XP_054219393.1  receptor-type tyrosine-protein phosphatase delta isoform X28

  4. XM_054363420.1 → XP_054219395.1  receptor-type tyrosine-protein phosphatase delta isoform X30

  5. XM_054363427.1 → XP_054219402.1  receptor-type tyrosine-protein phosphatase delta isoform X37

  6. XM_054363423.1 → XP_054219398.1  receptor-type tyrosine-protein phosphatase delta isoform X33

  7. XM_054363403.1 → XP_054219378.1  receptor-type tyrosine-protein phosphatase delta isoform X13

  8. XM_054363402.1 → XP_054219377.1  receptor-type tyrosine-protein phosphatase delta isoform X12

  9. XM_054363396.1 → XP_054219371.1  receptor-type tyrosine-protein phosphatase delta isoform X6

  10. XM_054363401.1 → XP_054219376.1  receptor-type tyrosine-protein phosphatase delta isoform X11

  11. XM_054363413.1 → XP_054219388.1  receptor-type tyrosine-protein phosphatase delta isoform X23

  12. XM_054363397.1 → XP_054219372.1  receptor-type tyrosine-protein phosphatase delta isoform X7

  13. XM_054363433.1 → XP_054219408.1  receptor-type tyrosine-protein phosphatase delta isoform X43

  14. XM_054363432.1 → XP_054219407.1  receptor-type tyrosine-protein phosphatase delta isoform X42

  15. XM_054363424.1 → XP_054219399.1  receptor-type tyrosine-protein phosphatase delta isoform X34

  16. XM_054363421.1 → XP_054219396.1  receptor-type tyrosine-protein phosphatase delta isoform X31

  17. XM_054363409.1 → XP_054219384.1  receptor-type tyrosine-protein phosphatase delta isoform X19

  18. XM_054363405.1 → XP_054219380.1  receptor-type tyrosine-protein phosphatase delta isoform X15

  19. XM_054363422.1 → XP_054219397.1  receptor-type tyrosine-protein phosphatase delta isoform X32

  20. XM_054363419.1 → XP_054219394.1  receptor-type tyrosine-protein phosphatase delta isoform X29

  21. XM_054363407.1 → XP_054219382.1  receptor-type tyrosine-protein phosphatase delta isoform X17

  22. XM_054363404.1 → XP_054219379.1  receptor-type tyrosine-protein phosphatase delta isoform X14

  23. XM_054363416.1 → XP_054219391.1  receptor-type tyrosine-protein phosphatase delta isoform X26

  24. XM_054363395.1 → XP_054219370.1  receptor-type tyrosine-protein phosphatase delta isoform X5

  25. XM_054363399.1 → XP_054219374.1  receptor-type tyrosine-protein phosphatase delta isoform X9

  26. XM_054363392.1 → XP_054219367.1  receptor-type tyrosine-protein phosphatase delta isoform X2

  27. XM_054363415.1 → XP_054219390.1  receptor-type tyrosine-protein phosphatase delta isoform X25

  28. XM_054363400.1 → XP_054219375.1  receptor-type tyrosine-protein phosphatase delta isoform X10

  29. XM_054363411.1 → XP_054219386.1  receptor-type tyrosine-protein phosphatase delta isoform X21

  30. XM_054363394.1 → XP_054219369.1  receptor-type tyrosine-protein phosphatase delta isoform X4

  31. XM_054363412.1 → XP_054219387.1  receptor-type tyrosine-protein phosphatase delta isoform X22

  32. XM_054363398.1 → XP_054219373.1  receptor-type tyrosine-protein phosphatase delta isoform X8

  33. XM_054363410.1 → XP_054219385.1  receptor-type tyrosine-protein phosphatase delta isoform X20

  34. XM_054363393.1 → XP_054219368.1  receptor-type tyrosine-protein phosphatase delta isoform X3

  35. XM_054363408.1 → XP_054219383.1  receptor-type tyrosine-protein phosphatase delta isoform X18

  36. XM_054363389.1 → XP_054219364.1  receptor-type tyrosine-protein phosphatase delta isoform X1

  37. XM_054363391.1 → XP_054219366.1  receptor-type tyrosine-protein phosphatase delta isoform X1

  38. XM_054363431.1 → XP_054219406.1  receptor-type tyrosine-protein phosphatase delta isoform X41

  39. XM_054363430.1 → XP_054219405.1  receptor-type tyrosine-protein phosphatase delta isoform X40

  40. XM_054363417.1 → XP_054219392.1  receptor-type tyrosine-protein phosphatase delta isoform X27

  41. XM_054363429.1 → XP_054219404.1  receptor-type tyrosine-protein phosphatase delta isoform X39

  42. XM_054363414.1 → XP_054219389.1  receptor-type tyrosine-protein phosphatase delta isoform X24

  43. XM_054363426.1 → XP_054219401.1  receptor-type tyrosine-protein phosphatase delta isoform X36

  44. XM_054363425.1 → XP_054219400.1  receptor-type tyrosine-protein phosphatase delta isoform X35

  45. XM_054363406.1 → XP_054219381.1  receptor-type tyrosine-protein phosphatase delta isoform X16

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23468.2 GenPept UniProtKB/Swiss-Prot:P23468

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